Pete Prisco shares his Week 12 NFL predictions, including some intriguing matchups and potential upsets. Here’s a look at his picks for this week, including key insights and analysis.
Week 12 Predictions
Pittsburgh Steelers (-3.5) at Cleveland Browns
- Kickoff: Thursday, 8:15 p.m. ET (Prime Video)
- Pick: Steelers 20, Browns 17
- Analysis: The Steelers are in solid form, while the Browns are struggling. Expect a close game, but Pittsburgh will edge out a victory with a late field goal.
Kansas City Chiefs (-11) at Carolina Panthers
- Kickoff: Sunday, 1 p.m. ET (CBS, Paramount+)
- Pick: Chiefs 32, Panthers 13
- Analysis: After their first loss, the Chiefs will come out strong against a Panthers team that is outmatched. Kansas City is set to bounce back decisively.
Minnesota Vikings (-3.5) at Chicago Bears
- Kickoff: Sunday, 1 p.m. ET (Fox, fubo free trial)
- Pick: Vikings 23, Bears 17
- Analysis: The Vikings have been resilient on the road, and they will rely on their defense to contain Bears QB Caleb Williams, leading to a narrow victory.
Tennessee Titans at Houston Texans (-8)
- Kickoff: Sunday, 1 p.m. ET (CBS, Paramount+)
- Pick: Texans 31, Titans 21
- Analysis: The Texans, with a rejuvenated offense, are poised to take advantage of a Titans team struggling to keep pace.
Detroit Lions (-7.5) at Indianapolis Colts
- Kickoff: Sunday, 1 p.m. ET (Fox, fubo free trial)
- Pick: Lions 30, Colts 17
- Analysis: The Lions’ potent offense will prove too much for the Colts, who are facing a step up in competition.
New England Patriots at Miami Dolphins (-7)
- Kickoff: Sunday, 1 p.m. ET (CBS, Paramount+)
- Pick: Dolphins 32, Patriots 21
- Analysis: The Dolphins are rolling, and Tua Tagovailoa’s return to form will be a challenge for the Patriots on the road.
Tampa Bay Buccaneers (-5.5) at New York Giants
- Kickoff: Sunday, 1 p.m. ET (CBS, Paramount+)
- Pick: Bucs 27, Giants 13
- Analysis: With Tommy DeVito under center for the Giants, the Bucs are expected to control the game and secure a comfortable win.
Dallas Cowboys at Washington Commanders (-10)
- Kickoff: Sunday, 1 p.m. ET (Fox, fubo free trial)
- Pick: Commanders 31, Cowboys 16
- Analysis: The Commanders, benefiting from extra rest, will capitalize on the Cowboys’ struggles to deliver a convincing win.
Denver Broncos (-5.5) at Las Vegas Raiders
- Kickoff: Sunday, 4:05 p.m. ET (CBS, Paramount+)
- Pick: Broncos 20, Raiders 17
- Analysis: A tight matchup expected, but the Broncos will find a way to win, relying on their defense to keep the Raiders in check.
San Francisco 49ers at Green Bay Packers (-2.5)
- Kickoff: Sunday, 4:25 p.m. ET (Fox, fubo free trial)
- Pick: Packers 27, 49ers 20
- Analysis: The Packers look to capitalize on their home field and a struggling 49ers team, aiming for redemption after last year’s playoff matchup.
Arizona Cardinals (-1) at Seattle Seahawks
- Kickoff: Sunday, 4:25 p.m. ET (Fox, fubo free trial)
- Pick: Cardinals 23, Seahawks 20
- Analysis: Coming off a bye, the Cardinals will leverage Kyler Murray’s playmaking ability to secure a critical division win.
Philadelphia Eagles (-3) at Los Angeles Rams
- Kickoff: Sunday, 8:20 p.m. ET (NBC, fubo free trial)
- Pick: Rams 28, Eagles 21
- Analysis: In what may be a surprising upset, the Rams are expected to take advantage of their home crowd and a banged-up Eagles squad.
Baltimore Ravens (-3) at Los Angeles Chargers
- Kickoff: Monday, 8:15 p.m. ET (ESPN, fubo free trial)
- Pick: Chargers 31, Ravens 26
- Analysis: The Chargers, riding high after a solid performance against the Bengals, will look to exploit the Ravens’ recent struggles.
Note: These predictions reflect Prisco’s insights and analysis for Week 12. As always, the landscape of the NFL can change rapidly, and these picks may evolve as game day approaches.